Register as an RSTCALC user and download the package
RSTCALC is a PC-based program for performing analyses of population
structure, genetic differentiation and gene flow using microsatellite data.
RSTCALC calculates estimates of Rst, a measure of genetic differentiation
analogous to Fst, which are unbiased with respect to differences in sample
size between populations and differences in variance between loci.
The program provides options to use permutation tests to determine if
Rst estimates are significantly different from zero, and bootstrapping to
obtain 95% confidence intervals for Rst and associated Nm estimates.
In addition you can also use RSTCALC to obtain estimates of the
delta-mu^2 distance measure.
RSTCALC is designed to offer a quick, simple approach to performing
comprehensive analyses of population structure. The program can be
applied to any diploid microsatellite data set. The program should run
on any PC from a 286 upwards and under Windows 95. A maths co-processor is
not necessary but does reduce computation time when large numbers of
permutations or bootstraps are being carried out.
Register as an RSTCALC user and download the package
Information on recent updates to RSTCALC
A short communication describing the calculations performed by the program has been published in the journal Molecular
Ecology. Goodman, SJ 1997. Rst Calc: a collection of computer programs for calculating estimates of genetic differentition from microsatellite data and a determining their significance.Molecular Ecology 6, 881-885.
Please watch this space for further information or feel free to email me, Simon Goodman, to find out more.
| MICROSAT | Calculates a comprehensive set of population genetic statistics for microsatellite data. |
|---|---|
| GENEPOP | All encompassing population genetics analysis. (Raymond & Rousset 1995, J. Heredity 83: 239). |
| ARLEQUIN | All encompassing population genetics analysis. Produced by Laurent Excoffier. |
| GENETIX | Offers similar analysis options to genepop for Windows 95. Currently front end is in French only (Bonhomme et al. Laboratoire Genome et Populations Universit de Montpellier). |
| LAMARC | Computes effective population size, population growth rate and migration rates using likelihoods for sequences, microsatellites, and electrophoretic polymorphisms. LAMARC is produced by Peter Beerli of the University of Washington. |
| PHYLIP | Includes PHYLIP and many other phylogeny packages. |
| SLATKIN LAB | Software from the lab of Montgomery Slatkin, including Ramus Nielsen's program for log likelihood analysis of microsatellite population data (Genetics 146: 711-716). |
OTHER SITES OF INTEREST
The Cavalli-Sforza
lab (Stanford) web-site has helpful descriptions of genetic distance
measures and information on other aspects of population genetics.
Return to the Evolution at
Edinburgh home page.